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Metabolomic Profiling and Modeling for Untargeted Chemical Analysis

Joshua Kellogg, PhD, Assistant Professor, Veterinary and Biomedical Sciences, The Pennsylvania State University

Date and Location

When (Date/Time)

February 20, 2020, 4:00 PM - 5:00 PM

Where

252 Erickson Food Science Building

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Natural products, dietary supplements, environmental samples, and nutraceutical and food matrices are all examples of complex systems that contain up to thousands of unique structures, an undetermined number of which can possess bioactive properties or serve as biomarkers. Traditional approaches to chemical analysis and biomarker identification can be labor- and resource-intensive, especially when dealing with unknown or novel compounds in low abundance. Metabolomics is an experimental approach that uses a holistic analysis of the chemical composition of a complex system to understand how chemical modifications underpin observed phenotypes. The analytical potential can be further expanded by correlating metabolomics analysis with variations in biological activity using a statistical modeling approach, a method known as biochemometrics. These approaches are broadly applicable, with examples including dietary supplement adulteration, antibiotic discovery, plant microbiome and ecology investigations, and synergy in complex systems.