Matthew D. Moore, Assistant Professor, University of Massachusetts

When September 17, 2020, 3:30 PM - 5:00 PM

Where Vitrual Online

Highly transmissible eukaryotic viruses continue to exact a considerable public health burden globally; a burden that has been drastically exacerbated by the current SARS-CoV-2 pandemic. Although not as severe as SARS-CoV-2, human noroviruses also cause pandemics and impose a considerable public health and economic burden, as they are the leading cause of foodborne illnesses in the U.S. Our lab utilizes applied and environmental virological paradigms to address some of the challenges such highly transmissible viruses present. Specifically, our lab is investigating the interactions and influences the enteric microflora may have on viral pathogenesis. Some evidence suggests that enteric bacteria can assist eukaryotic viral infection in the gut. The effects—both positive and/or negative—such bacteria have and the nature of their interaction is not well characterized for a number of viruses. Further, we have developed and are developing multiple promising rapid detection methods, including: a portable nanopore-based sensing platform with potential to rapidly detect and subtype pathogens; a portable isothermal amplification based assay capable of detecting viruses in 20 minutes or less; and a novel upstream virus concentration method for effectively and cheaply concentrating low numbers of viruses from food and environmental samples. We are also currently doing working to improve control of these viruses by restructuring antiviral natural disinfectants in a number of ways to improve their efficacy both on virus and in feasibility of application. Finally, we are also starting work to better understand how the structural dynamics of viral particles can enhance viral resistance to inactivation and persistence in the environment.