Share

vCard

John E. Hayes, Ph.D.

  • Associate Professor of Food Science
  • Director, Sensory Evaluation Center
John  E. Hayes, Ph.D.
220 Rodney A. Erickson Food Science Building
University Park, PA 16802
Email:
Work Phone: 814-863-7129

Areas of Expertise

  • Sensory science
  • Human psychophysics
  • Taste biology
  • Drug delivery systems
  • Food choice
  • Ingestive behavior
  • Consumer acceptability

Education

  1. Postdoc, Brown University, Alcohol/Behavioral Genetics
  2. Ph.D., University of Connecticut, Nutrition
  3. Graduate Certificate, University of Connecticut, Quantitative Research Methods (Psychology)
  4. M.S., Cornell University, Food Science (Sensory Science)
  5. B.S., Cornell University, Food Science

Research Interests:

Dr. Hayes' research group studies food choice in a biobehavioral framework, by integrated traditional sensory science methods with behavioral genetics to understand biological factors that may cause individuals to like and consume some foods but not others. Dr. Hayes is also interested in using sensory science methods to increase the user acceptability of various drug delivery systems.

Recent projects in his laboratory have focused on:

  • The psychophysics of taste and flavor perception
  • Quantifying the role of genetic variation on food sensations and reward
  • Understanding how genetic variation may or may not influence patterns of food intake
  • The role of personality in spicy food liking
  • Individual differences in the perception and liking of non-nutritive sweeteners, and the genetic basis of this variation
  • Factors which influence alcohol intake
  • Development of new psychophysical methods to predict consumer acceptability
  • Oral irritation from pharmaceutical agents
  • User acceptability of semisolid drug delivery systems for HIV prevention

Awards

  • Barry Jacobs Memorial Award for Research on the Psychophysics of Human Taste and Smell (Association for Chemoreception Sciences) 2016
  • Elsevier Food Quality and Preference Investigator of the Future Award 2015  
  • Roy C. Buck Award (Penn State College of Agricultural Sciences) 2013
  • Ajinomoto Award for Young Investigators in Gustation (Association for Chemoreception Sciences) 2011
  • Rose Marie Pangborn Sensory Science Scholarship 2006

Affiliations:

Graduate Program in Neuroscience, Huck Institutes of the Life Sciences, Penn State

Graduate Program in Nutrition, College of Health and Human Development, Penn State

Peer Reviewed Publications:


Hayes JE, Johnson S. 2017.Sensory Aspects of Bitter and Sweet Tastes during Early Childhood. Nutrition Today. Accepted 16 Jan 2017

Tenney K, Hayes JE, Euston SR, Elias RJ, Coupland JN. 2016. Binding of Caffeine and Quinine by Whey Protein and the Effect on Bitterness. J Food Sci. Accepted 29 Nov 2016.

Bitzer ZT, Wopperer AL, Chrisfield BJ, Tao L, Cooper TK, Vanamala J, Elias RJ, Hayes JE. 2016. Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo. J Nutrit Biochem. 40:201-208. Epub 27 Nov 2016. doi:10.1016/j.jnutbio.2016.11.012

Pickering GJ, Hayes JE. Influence of Biological, Experiential and Psychological Factors in Wine Preference Segmentation. Australian Journal of Grape and Wine Research. Accepted 9 Oct 2016. NIHMSID: 82835.

Running CA, Ziegler GJ, Hayes JE. 2016. Degree of free fatty acid saturation influences chocolate rejection in human assessor. Chem Senses. Epub 20 Nov 2016. doi: 10.1093/chemse/bjw116

Ziegler GR, Hayes JE, Lambert JD. Chocolate not necessarily healthier or tastier. PNAS. Accepted 12 Sept 2016.

Running CA, Hayes JE. Expectation and expectoration: information manipulation alters spitting volume, a common proxy for salivary flow. Physiol Behav. 167:180187. Epub 20 Sept 2016. doi: 10.1016/j.physbeh.2016.09.006

Nolden AA, Hayes JE. 2017. Perceptual and Affective Responses to Sampled Capsaicin Differ by Reported Intake. Food Qual Pref. 55:26-34. Epub 9 Aug 2016. doi: 10.1016/j.foodqual.2016.08.003

Zaveri T, Running CA, Surapaneni L, Ziegler GR, Hayes JE. 2016. Innovative Sensory Methods to Assess Acceptability of Mixed Polymer Semisoft Ovules for Microbicide Applications. Drug Deliv Transl Res. 6(5), 551-564. Epub 29 June 2016. doi: 10.1007/s13346-016-0309-8

Fleming EF, Ziegler GR, Hayes JE. Investigating Mixture Interactions of Astringent Stimuli using the Isobole Approach. Chem Senses. 41(7):601-610. Epub 1 June 2016. doi:10.1093/chemse/bjw064

Perry DM, Hayes JE. 2016. Effects of Matrix Composition on Detection Threshold Estimates for methyl anthranilate and 2-aminoacetophenone. Foods. 5(2):35. Epub 17 May 2016. doi:10.3390/foods5020035

Byrnes NK, Hayes JE. 2016. Behavioral measures of risk tasking, sensation seeking and sensitivity to reward may reflect different motivations for spicy food liking and consumption. Appetite. 103:411-422. Epub 29 April 2016. doi:10.1016/j.appet.2016.04.037.

Fleming EF, Ziegler GR, Hayes JE. 2016. Salivary protein levels as a predictor of perceived astringency in model systems and solid foods. Physiol Behav. 163:56-63. Epub 27 April 2016. doi:10.1016/j.physbeh.2016.04.043

Primrose RJ, Zaveri T, Bakke AJ, Ziegler GR, Moskowitz HR, Hayes JE. 2016. Drivers of vaginal drug delivery system acceptability from internet-based conjoint analysis. PLoS One. 11(3): e0150896. Epub 21 Mar 2016. doi 10.1371/journal.pone.0150896

Sanyal S, O’Brien SM, Hayes JE, Feeney EL. 2016. TongueSim: Development of an automated method for rapid assessment of fungiform papillae density for taste research. Chem Senses. Epub 17 Feb 2016. doi: 10.1093/chemse/bjw008.

Nolden AA, McGeary JE, Hayes JE. 2016. Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes. Physiol Behav. 156:117-27. Epub 2016 Jan 16. doi: 10.1016/j.physbeh.2016.01.017

Bakke AJ, †Shehan C, Hayes JE. 2016. Type of milk typically consumed, and stated preference, but not health consciousness affect revealed preferences for fat in milk. Food Qual Pref. 49:92-99. Epub 8 Dec 2015. doi:10.1016/j.foodqual.2015.12.001

Nolden AA, Hayes JE. 2015. Perceptual qualities of ethanol depend on concentration, and variation in these percepts associates with drinking frequency. Chemosen Percept.  8(3):149-157. Epub 19 Sept 2015. doi:10.1007/s12078-015-9196-5

Kelley K, Primrose RJ, Crassweller R, Hayes JE, Marini R. 2015. Consumer Peach Preferences and Purchasing Behavior: a mixed methods study. Journal of the Science of Food and Agriculture. In press. Epub 6 Aug 2015 doi:10.1002/jsfa.7365

Byrnes NK, Loss C, Hayes JE. 2015. Perception of chemesthetic stimuli in groups who differ by food involvement and culinary experience. Food Qual Pref. 46: 142-150. Epub 27 July 2015. doi: 10.1016/j.foodqual.2015.07.017

Webb J, Bolhuis D, Cicerale S, Hayes JE, Keast RSJ. 2015. The relationships between common measurements of taste function. Chemo Percept. 8(1):11-18. Epub 5 Jun 2015. doi: 10.1007/s12078-015-9183-x

Fleming EF, Ziegler GR, Hayes JE. 2015. Check-All-That-Apply (CATA), Sorting, and Polarized Sensory Positioning (PSP) with Astringent Stimuli. Food Qual Prefer 45: 41-49. Epub 1 June 2015. doi:10.1016/j.foodqual.2015.05.004

Hayes JE, Feeney EF, Nolden AA, McGeary JE. 2015. Quinine bitterness and grapefruit liking associate with allelic variants in TAS2R31. Chemical Senses. 40(6):437-443. Epub 29 May 2015. doi: 10.1093/chemse/bjv027.

Byrnes NK, Nestrud M Hayes JE. 2015. Perceptual mapping of chemesthetic stimuli in naïve assessors. Chemo Percept. 8(1):19-32. Epub 22 March 2015. doi:10.1007/s12078-015-9178-7.

Li B, Hayes JE, Ziegler GR. 2015. Maximizing overall liking results in a superior product to minimizing deviations from ideal ratings: an optimization case study with coffee-flavored milk. Food Qual Prefer. 42:27-36. Epub 20 Jan 2015.

Byrnes NK, Hayes JE. 2015. Gender differences in the influence of personality traits on spicy food liking and intake. Food Qual Prefer. 42:12-19. Epub 9 Jan 2015. doi:10.1016/j.foodqual.2015.01.002

Antenucci RG, Hayes JE. 2015. Non-nutritive sweeteners are not supernormal stimuli. Int J Obesity. 39:254-259. Epub 22 July 2014. doi: 10.1038/ijo.2014.109

Coupland JN, Hayes JE. 2014. Physical Approaches to Masking Bitter Taste: Lessons from Food and Pharmaceuticals. Pharmaceutical Research. 31(11):2921-2939. Epub 10 Sept 2014. doi:10.1007/s11095-014-1480-6

Allen AL, McGeary JE, Hayes JE. 2014. Polymorphisms in TRPV1 and TAS2Rs associate with sensations from sampled ethanol. Alcoholism Clinical and Experimental Research. 38(10):2550-2560. Epub 25 Sept 2014.

Zaveri T, Primrose R, Surapaneni L, Ziegler GR, Hayes JE. 2014. Firmness Perception Influences Women’s Preferences for Vaginal Suppositories. Pharmaceutics. 6(3), 512-529; doi:10.3390/ pharmaceutics6030512

Mahan ED, Zaveri T, Ziegler GR, Hayes JE. 2014. Relationships between perceptual attributes and rheology in over-the-counter vaginal products: a potential tool for microbicide development. PLoS One. 9(9): e105614. doi:10.1371/journal.pone.0105614.

Zaveri T, Hayes JE, Ziegler GR. 2014. Release of Tenofovir from Carrageenan-based Vaginal Suppositories. Pharmaceutics. 6(3):366-77. Epub 4 July 2014. doi:10.3390/pharmaceutics6030366.

Antenucci RG, Hayes JE. 2014. Non-nutritive sweeteners are not supernormal stimuli. International Journal of Obesity (Lond). Epub 22 July 2014. doi: 10.1038/ijo.2014.109

Garneau NL, Nuessle TM, Sloan MM, Santorico SA, Coughlin BC, Hayes JE. 2014. Crowdsourcing taste research: genetic and phenotypic predictors of bitter taste perception as a model. Front Integr Neurosci. 8:33. Epub 27 May 2014. doi:10.3389/fnint.2014.00033

Li B, Hayes JE, Ziegler GR. 2014. Just-About-Right and ideal scaling provide similar insights into the influence of sensory attributes on liking. Food Qual Prefer. 37:71-78. Epub 10 May 2014. doi:/10.1016/j.foodqual.2014.04.01

Feeney EL, Hayes JE. 2014. Regional differences in suprathreshold intensity for bitter and umami stimuli. Chemosensory Perception. Accepted 5 March 2014. Epub 13 May 2014. Doi:/10.1007/s12078-014-9166-3

Li B, Hayes JE, Ziegler GR. 2014. Interpreting consumer preferences: physicohedonic and psychohedonic models yield different information in a coffee-flavored dairy beverage. Food Qual Prefer. 36(1):27-32. Epub 15 Mar 2014. doi:/10.1016/j.foodqual.2014.03.001

Feeney EL, Hayes JE. 2014. Exploring associations between taste perception, oral anatomy and polymorphisms in the carbonic anhydrase (gustin) gene CA6. Physiol Behav. 128:148-154 Epub 15 Feb 2014. doi:10.1016/j.physbeh.2014.02.013

Hayes JE, Raines CR, DePasquale DA, Cutter CN. 2014. Consumer acceptability of high hydrostatic pressure (HHP)-treated ground beef patties. LWT-Food Science and Technology. 56(1):207-210. Epub 21 Nov 2013. doi:10.1016/j.lwt.2013.11.014

Rawal S, Hayes JE, Wallace MR, Bartoshuk LM, Duffy VB. 2013. Do polymorphisms in the TAS1R1 gene contribute to broader differences in human taste intensity? Chem Senses. 38(8):719-728. Epub 2 Sept 2013. doi:10.1093/chemse/bjt040

Hayes JE, Feeney EL, Allen AL. 2013. Do polymorphisms in chemosensory genes matter for human ingestive behavior?. Food Qual Pref. 30(2): 202–216. doi:10.1016/j.foodqual.2013.05.013

Harwood ML. Ziegler GR, and Hayes JE. 2013. Tolerance For High Flavanol Cocoa Powder in Semisweet Chocolate. Nutrients. 5(6): 2258-2267. Epub 21 June 2013.

Allen A, McGeary JE, Hayes JE. 2013. Rebaudioside A and Rebaudioside D bitterness do not covary with Acesulfame K bitterness or polymorphisms in TAS2R9 and TAS2R31. Chemos Percept. 6(3):109-117. doi: 10.1007/s12078-013-9149-9.

Harwood ML. Loquasto J, Roberts RF, Ziegler GR, and Hayes JE. 2013. Bitterness tolerance in chocolate ice cream. J Dairy Sci. Epub 13 June 2013. doi:10.3168/jds.2013-6715.

Allen A, McGeary JE, Knopik V, Hayes JE. Bitterness of the non-nutritive sweetener Acesulfame Potassium varies with polymorphisms in TAS2R9 and TAS2R31. Chemical Senses. 38(5):379-389. Epub 18 Apr 2013

Li B, Zaveri T, Ziegler GR, and Hayes JE. 2013. Shape of vaginal suppositories affects willingness-to-try and preference. Antiviral Research. Epub 29 Dec 2012. doi:10.1016/j.antiviral.2012.12.024

Li B, Zaveri T, Ziegler GR, and Hayes JE. 2013. User preferences in a carrageenan-based vaginal drug delivery system. PLoS One. 8(1). Epub 24 Jan 2013. doi: 10.1371/journal.pone.0054975

Sharafi M, Hayes JE, and Duffy VB. 2013. Masking vegetable bitterness to improve palatability depends on vegetable type and tastephenotype. Chemosensory Perception. Epub 28 Dec 2012. doi:10.1007/s12078-012-9137-5

Byrnes NK, and Hayes JE. 2013. Personality factors predict spicy food liking and intake. Food Qual Pref. 28(1): 213-221. Epub 4 Oct 2012.doi:10.1016/j.foodqual.2012.09.008

Hayes JE, Allen AL, and Bennett SM. 2013. Direct comparison of the generalized Visual Analog Scale (gVAS) and general Labeled Magnitude Scale (gLMS). Food Qual Pref. 28(1): 36-44. Epub 10 Aug 2012.doi:10.1016/j.foodqual.2012.07.012 

Bennett SM, Zhou L, and Hayes JE. 2012. Using milk fat to reduce the irritation and bitter taste of ibuprofen. Chemosensory Perception.5(3-4):231-236. Epub 1 May 2012. doi: 10.1007/s12078-012-9128

Harwood ML. Ziegler GR, and Hayes JE. 2012. Rejection Thresholds in Solid Chocolate-Flavored Compound Coating. J Food Sci. 77(10):S390-S393. Epub 27 Aug 2012. doi: 10.1111/j.1750-3841.2012.02889.x

McGeary JE, Knopik VS, Hayes JE, Palmer RH, Monti P, Kalman D. Predictors of relapse in a bupropion trial for smoking cessation in recently-abstinent alcoholics: Preliminary results using an aggregate genetic risk score. Substance Abuse Research and Treatment. In press

Bennett SM, Zhou L, and Hayes JE. Using milk fat to reduce the irritation and bitter taste of ibuprofen. Chemosensory Perception. In press. Epub 1 May 2012. doi: 10.1007/s12078-012-9128-6.

Harwood ML. Ziegler GR, and Hayes JE. 2012. Rejection Thresholds in Chocolate Milk: Evidence for Segmentation. Food Qual Pref. 26(1): 128­133. Epub 21 Apr 2012, doi: 10.1016/j.foodqual.2012.04.009.

Bennett SM, Hayes JE. 2012. Differences in the chemesthetic sub-qualities of capsaicin, ibuprofen and olive oil. Chemical Senses. 37(5): 471-478 Epub 25 Jan 2012 doi:10.1093/chemse/bjr129.

Harrington HL, Kennedy KE, Sharafi M, Hayes JE, Duffy VB. 2012. Otitis media exposure associates with dietary preference and adiposity: A community-based observational study of at-risk preschoolers. Physiol Behav. 106(2):264-271. Epub 6 Feb 2012, doi: 10.1016/j.physbeh.2012.01.021.

Hayes JE, Pickering GJ. 2012. Wine expertise predicts taste phenotype. Am J Enol Viti. 63(1):80-84. Epub 2011 October, doi: 10.5344/ajev.2011.11050.

Hayes JE, Keast RSJ. 2011. Two decades of supertasting: where do we stand?
Physiol Behav. 104(5): 1072-1074. Epub 2011 Aug 7,
doi:10.1016/j.physbeh.2011.08.003.

Hayes JE, Keast RSJ. Two decades of supertasting: where do we stand? Physiol Behav. In press. Epub 2011 Aug 7, doi:10.1016/j.physbeh.2011.08.003

Hayes JE, DePasquale DA, Moser SE. 2011. Asymmetric dominance as a potential source of bias in hedonic testing. Food Quality and Preference. 22(6):559-566. Epub 2011 Mar 21. doi:10.1016/j.foodqual.2011.03.006

Mahan ED, Morrow KN, Hayes JE. 2011. Quantitative perceptual differences among over-the-counter vaginal products using a standardized methodology: implications for microbicide development. Contraception. 84(2):184-93. Epub 2011 Jan 10, doi:10.1016/j.contraception.2010.11.012

Hayes JE, Knopik VS, et al. 2011. Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors towards common bitter beverages in adults. Chem Senses. 36(3):311-9. Epub 2010 Dec 16. doi:10.1093/chemse/bjq132

Duffy VB, Hayes JE, et al. 2010. Vegetable intake in college-aged adults is explained by oral sensory phenotypes and TAS2R38 genotype. Chemosensory Perception. 3(3):137-148. Epub 2010 Aug 1. doi:10.1007/s12078-010-9079-8

Duffy VB, Hayes JE, et al. 2010. ³Vegetable intake in college-aged adults is explained by oral sensory phenotypes and TAS2R38 genotype." Chemosensory Perception. Epub 2010 Aug 1. doi:10.1007/s12078-010-9079-8

Hayes JE, Sullivan BS, Duffy VB. 2010. "Explaining variability in sodium intake through oral sensory phenotype, salt sensation and liking." Physiol Behav. 100(4): 369-380. Epub 2010 April 7,  doi:10.1016/j.physbeh.2010.03.017.

Hayes JE. 2010. "Response to Lack of Relation Between Bitter Taste Receptor TAS2R38 and BMI in Adults." Obesity. 18, 433-433 (23 February 2010) doi:10.1038/oby.2009.351.

Duffy VB, Hayes JE, Sullivan BS, Faghri P. 2009. "Surveying Food/Beverage Liking: A Tool for Epidemiological Studies to Connect Chemosensation with Health Outcomes." Ann NY Acad Sci. 1170:558-568. doi: 10.1111/j.1749-6632.2009.04593.x.

Hayes, JE and Duffy VB. 2008. "Oral sensory phenotype identifies level of sugar and fat required for maximal liking." Physiology & Behavior 95(1-2): 77-87. Epub 2008 May 2, doi:10.1016/j.physbeh.2008.04.023.

Hayes JE, Bartoshuk LM, Kidd JK, Duffy VB. 2008. "Supertasting and PROP bitterness depends on more than the TAS2R38 gene." Chemical Senses 33(3): 255-265. Epub 2008 Jan 21, doi:10.1093/chemse/bjm084.

Hayes, JE. 2008. "Transdisciplinary perspectives on Sweetness." Chemosensory Perception 1(1):48-57. Epub 2007 December 11, doi: 10.1007/s12078-007-9003-z.

Hayes JE, Duffy VB. 2007. "Revisiting sugar-fat mixtures: sweetness and creaminess vary with phenotypic markers of oral sensation." Chemical Senses 32(3): 225-236. Epub 2007 Jan 4, doi:10.1093/chemse/bjl050.

Bartoshuk LM, Duffy VB, Hayes JE, Snyder DJ. 2006. "Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives." Philos Trans R Soc Lond B Biol Sci 361(1471): 1137-48.

Dinehart ME, Hayes JE, Bartoshuk LM, Lanier SL. & Duffy VB. 2005. "Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake." Physiology & Behavior, 87(2): 304-13.

Lanier SA, Hayes JE, Duffy VB. 2005. "Sweet and bitter tastes of alcoholic beverages mediate alcohol intake in of-age undergraduates." Physiology & Behavior 83(5): 821-831.

Green BG, Hayes JE. 2004. "Individual Differences in Perception of Bitterness from Capsaicin, Piperine and Zingerone." Chemical Senses 29(1): 53-60.

Green BG, Hayes JE. 2003. "Capsaicin as a probe of the relationship between bitter taste and chemesthesis." Physiology & Behavior 79(4-5): 811-821.

Horne J, Hayes J, Lawless HT. 2002. "Turbidity as a measure of salivary protein reactions with astringent substances." Chemical Senses 27(7): 653-9.

Invited Book Chapters:

Hayes JE. “Pungency and burn: historical perspectives, word usage, and temporal characteristics” In: Chemesthesis: chemical touch in food and eating. 2016. S. McDonald, D. Bolliet, J.E. Hayes (eds). Wiley.

Hayes JE. “Measuring sensory perception in relation to actual consumer behaviour” In: Rapid Sensory Profiling Techniques. 2015. J. Delarue, J. B. Lawlor and M. Rogeaux (eds). Woodhead Publishing. Cambridge. 53-69. ISBN 978-1782422488

Prescott J, Hayes JE, Byrnes NK. “Sensory science” In: Encyclopedia of Agriculture and Food Systems. 2014. NK Van Alfen (editor-in-chief). Elsevier. San Diego. 80-101. ISBN 978-0-444-52512-3

Corwin RL, Hayes JE, “Are sugars addictive? Perspectives for practitioners” In: Fructose, High Fructose Corn Syrup, Sucrose, and Health. James M. Rippe (editor). Springer. New York. 199-215. ISBN 978-1-4899-8077-9

Duffy VB, Hayes JE, “Smell, taste, and oral somatosensation: age-related changes and nutritional implications” In: Geriatric Nutrition: the Health Professional's Handbook. 2013. 4th ed. Jones & Bartlett Learning. Burlington MA. ISBN 9780763782627.

Duffy VB, Hayes JE, Bartoshuk LM, Snyder DJ. “Taste: vertebrate psychophysics.” In: Encyclopedia of Neuroscience. 2009. Squire L (ed in chief). Academic Press. Oxford. 881-885. doi:10.1016/B978-008045046-9.01674-0.

Snyder DJ, Duffy VB, Hayes JE, Bartoshuk LM. Propylthiouracil (PROP) taste. In: The Senses: A Comprehensive Reference. 2008. Basbaum et al (eds). Academic Press. New York. Vol 4, p. 391-399. doi: 10.1016/B978-012370880-9.00093-1.

Duffy VB, Hayes JE, Dinehart ME. “Genetic differences in sweet taste perception.” In: Optimising sweet taste in foods. 2006. Spillane WJ (ed). Woodhead Publishing Ltd. Cambridge.

Research Interests

Cocoa, Chocolate, and Confectionery Researchers

Flavor perception, behavioral genetics, and ingestive behavior; biological foundations of food liking and intake; Impact of genetic variation on food sensations and intake; Acquisition of preference for initially aversive stimuli.

Food Choice and Consumer Behavior

Flavor perception, behavioral genetics, and ingestive behavior; biological foundations of food liking and intake; Impact of genetic variation on food sensations and intake; Acquisition of preference for initially aversive stimuli.