John E. Hayes Ph.D.

Research Interests:

Dr. Hayes' research group studies food choice in a biobehavioral framework, by integrated traditional sensory science methods with behavioral genetics to understand biological factors that may cause individuals to like and consume some foods but not others. Dr. Hayes is also interested in using sensory science methods to increase the user acceptability of various drug delivery systems.

Recent projects in his laboratory have focused on:

• The psychophysics of taste and flavor perception
• Quantifying the role of genetic variation on food sensations and reward
• Understanding how genetic variation may or may not influence patterns of food intake
• The role of personality in spicy food liking
• Individual differences in the perception and liking of non-nutritive sweeteners, and the genetic basis of this variation
• Factors which influence alcohol intake
• Development of new psychophysical methods to predict consumer acceptability
• Oral irritation from pharmaceutical agents
• User acceptability of semisolid drug delivery systems for HIV prevention

Awards

• Roy C. Buck Award (Penn State College of Agricultural Sciences) 2013
  
• Ajinomoto Award for Young Investigators in Gustation (Association of Chemoreception Sciences) 2011
• Rose Marie Pangborn Sensory Science Scholarship 2006
  

Affiliations:

Graduate Program in Neuroscience, Huck Institutes of the Life Sciences, Penn State

Graduate Program in Nutrition, College of Health and Human Development, Penn State

Selected Publications:

Allen A, McGeary JE, Knopik V, Hayes JE. Bitterness of the non-nutritive sweetener Acesulfame Potassium varies with polymorphisms in TAS2R9 and TAS2R31. Chemical Senses. In press.

Li B, Zaveri T, Ziegler GR, and Hayes JE. 2013. Shape of vaginal suppositories affects willingness-to-try and preference. Antiviral Research. Epub 29 Dec 2012. doi:10.1016/j.antiviral.2012.12.024

Li B, Zaveri T, Ziegler GR, and Hayes JE. 2013. User preferences in a carrageenan-based vaginal drug delivery system. PLoS One. 8(1). Epub 24 Jan 2013. doi: 10.1371/journal.pone.0054975

Sharafi M, Hayes JE, and Duffy VB. 2013. Masking vegetable bitterness to improve palatability depends on vegetable type and taste phenotype.Chemosensory Perception. Epub 28 Dec 2012. doi:10.1007/s12078-012-9137-5

Byrnes NK, and Hayes JE. 2013. Personality factors predict spicy food liking and intake. Food Qual Pref. 28(1): 213-221. Epub 4 Oct 2012.doi:10.1016/j.foodqual.2012.09.008

Hayes JE, Allen AL, and Bennett SM. 2013. Direct comparison of the generalized Visual Analog Scale (gVAS) and general Labeled Magnitude Scale (gLMS). Food Qual Pref. 28(1): 36-44. Epub 10 Aug 2012.doi:10.1016/j.foodqual.2012.07.012

Bennett SM, Zhou L, and Hayes JE. 2012. Using milk fat to reduce the irritation and bitter taste of ibuprofen. Chemosensory Perception.5(3-4):231-236. Epub 1 May 2012. doi: 10.1007/s12078-012-9128-6

Harwood ML. Ziegler GR, and Hayes JE. 2012. Rejection Thresholds in Solid Chocolate-Flavored Compound Coating. J Food Sci. 77(10):S390-S393. Epub 27 Aug 2012. doi: 10.1111/j.1750-3841.2012.02889.x

McGeary JE, Knopik VS, Hayes JE, Palmer RH, Monti P, Kalman D. Predictors of relapse in a bupropion trial for smoking cessation in recently-abstinent alcoholics: Preliminary results using an aggregate genetic risk score. Substance Abuse Research and Treatment. In press.

Bennett SM, Zhou L, and Hayes JE. Using milk fat to reduce the irritation and bitter taste of ibuprofen. Chemosensory Perception. In press. Epub 1 May 2012. doi: 10.1007/s12078-012-9128-6.

Harwood ML. Ziegler GR, and Hayes JE. 2012. Rejection Thresholds in Chocolate Milk: Evidence for Segmentation. Food Qual Pref. 26(1): 128­133.
Epub 21 Apr 2012, doi: 10.1016/j.foodqual.2012.04.009.

Bennett SM, Hayes JE. 2012. Differences in the chemesthetic sub-qualities of capsaicin, ibuprofen and olive oil. Chemical Senses. 37(5): 471-478 Epub 25 Jan 2012 doi:10.1093/chemse/bjr129.

Harrington HL, Kennedy KE, Sharafi M, Hayes JE, Duffy VB. 2012. Otitis media exposure associates with dietary preference and adiposity: A community-based observational study of at-risk preschoolers. Physiol Behav. 106(2):264-271. Epub 6 Feb 2012, doi: 10.1016/j.physbeh.2012.01.021.

Hayes JE, Pickering GJ. 2012. Wine expertise predicts taste phenotype. Am J Enol Viti. 63(1):80-84. Epub 2011 October, doi: 10.5344/ajev.2011.11050.

Hayes JE, Keast RSJ. 2011. Two decades of supertasting: where do we stand?
Physiol Behav. 104(5): 1072-1074. Epub 2011 Aug 7,
doi:10.1016/j.physbeh.2011.08.003.

Hayes JE, Keast RSJ. Two decades of supertasting: where do we stand? Physiol Behav. In press. Epub 2011 Aug 7, doi:10.1016/j.physbeh.2011.08.003

Hayes JE, DePasquale DA, Moser SE. 2011. Asymmetric dominance as a potential source of bias in hedonic testing. Food Quality and Preference. 22(6):559-566. Epub 2011 Mar 21. doi:10.1016/j.foodqual.2011.03.006

Mahan ED, Morrow KN, Hayes JE. 2011. Quantitative perceptual differences among over-the-counter vaginal products using a standardized methodology: implications for microbicide development. Contraception. 84(2):184-93. Epub 2011 Jan 10, doi:10.1016/j.contraception.2010.11.012

Hayes JE, Knopik VS, et al. 2011. Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors towards common bitter beverages in adults. Chem Senses. 36(3):311-9. Epub 2010 Dec 16. doi:10.1093/chemse/bjq132

Duffy VB, Hayes JE, et al. 2010. Vegetable intake in college-aged adults is explained by oral sensory phenotypes and TAS2R38 genotype. Chemosensory Perception. 3(3):137-148. Epub 2010 Aug 1. doi:10.1007/s12078-010-9079-8

Duffy VB, Hayes JE, et al. 2010. ³Vegetable intake in college-aged adults is explained by oral sensory phenotypes and TAS2R38 genotype." Chemosensory Perception. Epub 2010 Aug 1. doi:10.1007/s12078-010-9079-8

Hayes JE, Sullivan BS, Duffy VB. 2010. "Explaining variability in sodium intake through oral sensory phenotype, salt sensation and liking." Physiol Behav. 100(4): 369-380. Epub 2010 April 7,  doi:10.1016/j.physbeh.2010.03.017.

Hayes JE. 2010. "Response to Lack of Relation Between Bitter Taste Receptor TAS2R38 and BMI in Adults." Obesity. 18, 433-433 (23 February 2010) doi:10.1038/oby.2009.351.

Duffy VB, Hayes JE, Sullivan BS, Faghri P. 2009. "Surveying Food/Beverage Liking: A Tool for Epidemiological Studies to Connect Chemosensation with Health Outcomes." Ann NY Acad Sci. 1170:558-568. doi: 10.1111/j.1749-6632.2009.04593.x.

Hayes, JE and Duffy VB. 2008. "Oral sensory phenotype identifies level of sugar and fat required for maximal liking." Physiology & Behavior 95(1-2): 77-87. Epub 2008 May 2, doi:10.1016/j.physbeh.2008.04.023.

Hayes JE, Bartoshuk LM, Kidd JK, Duffy VB. 2008. "Supertasting and PROP bitterness depends on more than the TAS2R38 gene." Chemical Senses 33(3): 255-265. Epub 2008 Jan 21, doi:10.1093/chemse/bjm084.

Hayes, JE. 2008. "Transdisciplinary perspectives on Sweetness." Chemosensory Perception 1(1):48-57. Epub 2007 December 11, doi:10.1007/s12078-007-9003-z.

Hayes JE, Duffy VB. 2007. "Revisiting sugar-fat mixtures: sweetness and creaminess vary with phenotypic markers of oral sensation." Chemical Senses 32(3): 225-236. Epub 2007 Jan 4, doi:10.1093/chemse/bjl050.

Bartoshuk LM, Duffy VB, Hayes JE, Snyder DJ. 2006. "Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives." Philos Trans R Soc Lond B Biol Sci 361(1471): 1137-48.

Dinehart ME, Hayes JE, Bartoshuk LM, Lanier SL. & Duffy VB. 2005. "Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake." Physiology & Behavior, 87(2): 304-13.

Lanier SA, Hayes JE, Duffy VB. 2005. "Sweet and bitter tastes of alcoholic beverages mediate alcohol intake in of-age undergraduates." Physiology & Behavior 83(5): 821-831.

Green BG, Hayes JE. 2004. "Individual Differences in Perception of Bitterness from Capsaicin, Piperine and Zingerone." Chemical Senses 29(1): 53-60.

Green BG, Hayes JE. 2003. "Capsaicin as a probe of the relationship between bitter taste and chemesthesis." Physiology & Behavior 79(4-5): 811-821.

Horne J, Hayes J, Lawless HT. 2002. "Turbidity as a measure of salivary protein reactions with astringent substances." Chemical Senses 27(7): 653-9.