Ryan J. Elias, Ph.D.
- Professor and Associate Head of Food Science
University Park, PA 16802
- Email elias@psu.edu
- Office 814-865-5371
- PDF Curriculum Vitae
Areas of Expertise
- Food chemistry
- Enology
- Wine oxidation
- Hop chemistry
- Antioxidants
- Lipid oxidation
Websites
Education
- Postdoc, Viticulture & Enology, University of California-Davis
- Ph.D., Food Science, University of Massachusetts-Amherst, 2006
- B.A., Chemistry, Hamilton College, 2000
Research
Our group studies the free radical chemistry of foods, especially as it relates to understanding antioxidant and pro-oxidant mechanisms. Current research projects in our laboratory are in the following areas:
- Oxidative stability of wine and beer components
- Lipid oxidation in complex foods
- Use of electron paramagnetic resonance (EPR) to investigate free radical mechanisms in foods, tobacco products, and biological systems
- Small molecule partitioning in complex foods using EPR spin probes
- Redox chemistry and stability of polyphenols in foods
Honors and Awards
- Outstanding Collaborative Research Award, Penn State College of Medicine, 2018
- Community of Teaching Award, Penn State College of Agricultural Sciences, 2018
- Anna and Guy Bixler Memorial Teaching Award in Food Science, 2015
- Young Scientist Award, American Chemical Society, Agricultural and Food Chemistry Division, 2012
- Honored Student Award, American Oil Chemists' Society, 2005
Funding
Work in our group is, or has been, supported by the following agencies and organizations:
- Agriculture and Food Research Initiative, US Department of Agriculture (USDA)
- Specialty Crop Research Initiative, US Department of Agriculture (USDA)
- Tobacco Centers of Regulatory Science (P50), US National Institutes of Health (NIH) and US Food and Drug Administration (FDA)
- Northeast Sustainable Agriculture Research and Education, US Department of Agriculture (USDA)
- Pennsylvania Wine Marketing and Research Board, Pennsylvania Department of Agriculture (PDA)
- Pennsylvania Malt and Brewed Beverage Industry Promotion Board, Pennsylvania Department of Agriculture (PDA)
- Dairy Management Inc. (DMI)
Publications
Free Radicals in Little Cigar Mainstream Smoke and the Potential Influence of Flavoring Chemicals on Free Radical Production
Chemical Research in Toxicology, Mocniak, Leanne, Bitzer, Zachary T., Goel, Reema, Muscat, Joshua E., Foulds, Jonathan, Elias, Ryan J., Richie, John P., 2024
Impact of pre- and post-fermentation fining with polyvinylpolypyrrolidone on the chemical stability and aromatic profile of Viognier wine
Journal of Food Science, Van Buiten, Charlene B., Elias, Ryan J., 2024
Evaluation of vacuum drying on aroma quality of dried hops
Applied Engineering in Agriculture, Naziemiec, M, Ciolkosz, D, Anantheswaran, R, Elias, Ryan, 2024
The role of starch digestion in the brewing of gluten-free beers
Food Bioscience, Ledley, Andrew, Elias, Ryan, Cockburn, Darrell, 2024
Microscopic assessment of the degradation of millet starch granules by endogenous and exogenous enzymes during mashing
Carbohydrate Polymers, Ledley, Andrew, Ziegler, Gregory, Elias, Ryan, Cockburn, Darrell W., 2023
Evaluating the Role of Mashing in the Amino Acid Profiles of Worts Produced from Gluten-Free Malts
Beverages, Ledley, Andrew J., Elias, Ryan J., Cockburn, Darrell W., 2023
Impact of mashing protocol on the formation of fermentable sugars from millet in gluten-free brewing
Food Chemistry, Ledley, Andrew, Elias, R, Cockburn, Darrell, 2023
The effect of dessert-flavored e-cigarettes on brain function: A brief report
Neuropsychopharmacology, Hobkirk, A, Houser, K, Hoglen, B, Bitzer, Z, Fendrich, A, Bordner, C, Foulds, J, Mukherjee, D, Yingst, J, Karunanayakac, P, Goel, R, Wang, J, Richie, J, Elias, Ryan, Yang, Q, 2023
Effect of alkyl chain length on the antioxidant activity of alkylresorcinol homologs in low-moisture crackers
LWT, Elder, Andrew S., Coupland, John N., Hopfer, H, Elias, R, Hopfer, Helene, Elias, Ryan J., Andrew, Elder, 2022
Partitioning of caffeine and quinine in oil-in-water emulsions and effects on bitterness
Journal of Food Science, Elias, R, Tenney, K, Hayes, John, Tenney, Kelsey, Bakke, A, Coupland, John, Elias, Ryan, 2022
Impact of copper-based fungicides on the antioxidant quality of ethanolic hop extracts
Food Chemistry, Chrisfield, Benjamin J., Hopfer, Helene, Elias, Ryan J., 2021
Effect of alkyl chain length on the antioxidant activity of alkylresorcinol homologues in bulk oils and oil-in-water emulsions
Food Chemistry, Elder, Andrew S., Coupland, John N., Elias, Ryan J., 2021
Influence of region on sensory and chemical profiles of pennsylvania grüner veltliner wines
Foods, Keller, Stephanie T., Harner, Andrew D., Centinari, Michela, Elias, Ryan J., Hopfer, Helene, 2021
Gliadin sequestration as a novel therapy for celiac disease: A prospective application for polyphenols
International Journal of Molecular Sciences, Van Buiten, Charlene B., Elias, Ryan J., 2021
Evidence From an fMRI Study That Dessert-Flavored E-Cigarettes Engage Taste-Related, but Not Smoking-Related, Brain Circuitry for Female Daily Smokers
Experimental and Clinical Psychopharmacology, Hobkirk, Andr\'ea L, None, Hobkirk, Andrea, Houser, Kenneth, Hoglen, Brianna, Bitzer, Zachary, Fendrich, Alan, Frendrich, Alan, Bordner, Candace, Foulds, J, Wang, J, Mukherjee, D, Yingst, J, Mukherjee, Dahlia, Yingst, J, Karunanayakac, P, Karunanayaka, P, others, None, Goel, R, Goel, R, Wang, J, Richie, J, Elias, Ryan, Yang, Qing, Elias, R, Yang, Q, 2021
A modified brewing procedure informed by the enzymatic profiles of gluten-free malts significantly improves fermentable sugar generation in gluten-free brewing
Beverages, Ledley, Andrew, Elias, R, Hopfer, H, Cockburn, Darrell, 2021
Effect of Copper-Based Fungicide Treatments on the Quality of Hop Produced in the Northeastern United States
Journal of the American Society of Brewing Chemists, Chrisfield, B, Gugino, Beth, Hopfer, Helene, Elias, Ryan, 2021
Unburned Tobacco Cigarette Smoke Alters Rat Ultrastructural Lung Airways and DNA
Nicotine and Tobacco Research, Vivarelli, Fabio, Canistro, Donatella, Cirillo, Silvia, Elias, Ryan J., Granata, Silvia, Mussoni, Matilde, Burattini, Sabrina, Falcieri, Elisabetta, Turrini, Eleonora, Fimognari, Carmela, Buschini, Annamaria, Lazzaretti, Mirca, Beghi, Sofia, Girotti, Stefano, Sangiorgi, Stefano, Bolelli, Luca, Ghini, Severino, Ferri, Elida Nora, Fagiolino, Ivan, Franchi, Paola, Lucarini, Marco, Mercatante, Dario, Rodriguez-Estrada, Maria Teresa, Lorenzini, Antonello, Marchionni, Silvia, Gabriele, Morena, Longo, Vincenzo, Paolini, Moreno, 2021
Impact of Atomizer Age and Flavor on in Vitro Toxicity of Aerosols from a Third-Generation Electronic Cigarette against Human Oral Cells
Chemical Research in Toxicology, Ureña, José F., Ebersol, Lauren A., Silakov, Alexey, Elias, Ryan J., Lambert, Joshua D., 2020
Impact of copper fungicide use in hop production on the total metal content and stability of wort and dry-hopped beer
Beverages, Chrisfield, Benjamin J., Hopfer, Helene, Elias, Ryan J., 2020
An Electronic Aerosol Delivery System for Functional Magnetic Resonance Imaging
Substance Abuse: Research and Treatment, Hobkirk, Andréa L., Bitzer, Zachary, Goel, R, Sica, Christopher T., Livelsberger, Craig, Yingst, Jessica, Houser, Kenneth, Rupprecht, Sebastian, Trushin, N, Karunanayaka, Prasanna, Foulds, Jonathan, Richie, John P., Richie, Jr, J, Spreen, Lauren, Hoglen, Brianna, Wang, Jianli, Elias, Ryan J., Yang, Qing X., 2020
Microbial synergy between Pichia kudriazevii YS201 and Bacillus subtilis BS38 improves pulp degradation and aroma production in cocoa pulp simulation medium
Heliyon, Ouattara, Honoré G., Elias, Ryan J., Dudley, Edward G., 2020
Impact of electronic cigarette heating coil resistance on the production of reactive carbonyls, reactive oxygen species and induction of cytotoxicity in human lung cancer cells in vitro
Regulatory Toxicology and Pharmacology, Cirillo, Silvia, Urena, Jose F., Lambert, Joshua D., Vivarelli, Fabio, Canistro, Donatella, Paolini, Moreno, Cardenia, Vladimiro, Rodriguez-Estrada, Maria Teresa, Richie, John P., Elias, Ryan J., 2019
UV-C irradiated gallic acid exhibits enhanced antimicrobial activity via generation of reactive oxidative species and quinone
Food Chemistry, Wang, Qingyang, Leong, Wai Fun, Elias, Ryan J., Tikekar, Rohan V., 2019
Loss and formation of malodorous volatile sulfhydryl compounds during wine storage
Critical Reviews in Food Science and Nutrition, Kreitman, Gal Y., Elias, Ryan J., Jeffery, David W., Sacks, Gavin L., 2019
Evaluation of Antioxidant Activity and Interaction with Radical Species Using the Vesicle Conjugated Autoxidizable Triene (VesiCAT) Assay
European Journal of Lipid Science and Technology, Durand, Erwann, Zhao, Yu, Ruesgas-Ramón, Mariana, Figueroa-Espinoza, Maria Cruz, Lamy, Samantha, Coupland, John N., Elias, Ryan J., Villeneuve, Pierre, 2019
Physicochemical interactions with (-)-epigallocatechin-3-gallate drive structural modification of celiac-associated peptide α2-gliadin (57-89) at physiological conditions
Food and Function, Van Buiten, Charlene B., Yennawar, Neela H., Pacheco, Carlos N., Hatzakis, Emmanuel, Elias, Ryan J., 2019
Antioxidant activity of a winterized, acetonic rye bran extract containing alkylresorcinols in oil-in-water emulsions
Food Chemistry, Elder, Andrew S., Coupland, John N., Elias, Ryan J., 2019
In Vitro Antioxidant and Cancer Inhibitory Activity of a Colored Avocado Seed Extract
International Journal of Food Science, Dabas, Deepti, Elias, Ryan J., Ziegler, Gregory R., Lambert, Joshua D., 2019
Modeling the Impacts of Weather and Cultural Factors on Rotundone Concentration in Cool-Climate Noiret Wine Grapes
Frontiers in Plant Science, Harner, Andrew D., Vanden Heuvel, Justine E., Harner, Andrew, Marini, Richard P., Vanden Heuvel, J, Elias, Ryan J., Centinari, Michela, 2019
Effects of Charcoal on Carbonyl Delivery from Commercial, Research, and Make-Your-Own Cigarettes
Chemical Research in Toxicology, Reilly, Samantha, Goel, R, Trushin, Neil, Bitzer, Zachary, Elias, Ryan J., Muscat, Joshua, Richie, J, 2018
Characterization of amylose inclusion complexes using electron paramagnetic resonance spectroscopy
Food Hydrocolloids, Kong, Lingyan, Yucel, Umut, Yoksan, Rangrong, Elias, Ryan J., Ziegler, Gregory R., 2018
Inclusion complex formation between high amylose corn starch and alkylresorcinols from rye bran
Food Chemistry, Gunenc, Aynur, Kong, Lingyan, Elias, Ryan J., Ziegler, Gregory R., 2018
Effect of Charcoal in Cigarette Filters on Free Radicals in Mainstream Smoke
Chemical Research in Toxicology, Goel, R, Bitzer, Zachary, Reilly, Samantha, Bhangu, Gurkirat, Trushin, N, Elias, Ryan J., Foulds, Jonathan, Muscat, Joshua, Richie, John P., 2018
Little cigars, filtered cigars, and their carbonyl delivery relative to cigarettes
Nicotine and Tobacco Research, Reilly, Samantha, Goel, R, Bitzer, Zachary, Elias, Ryan J., Foulds, Jonathan, Muscat, Joshua, Richie, John P., 2018
Impact of roasting on the flavan-3-ol composition, sensory-related chemistry, and in vitro pancreatic lipase inhibitory activity of cocoa beans
Food Chemistry, Stanley, Todd H., Van Buiten, Charlene B., Baker, Scott A., Elias, Ryan J., Anantheswaran, Ramaswamy C., Lambert, Joshua D., 2018
Influence of Smoking Puff Parameters and Tobacco Varieties on Free Radicals Yields in Cigarette Mainstream Smoke
Chemical Research in Toxicology, Goel, R, Bitzer, Zachary, Reilly, Samantha, Foulds, Jonathan, Muscat, Joshua, Elias, Ryan, Richie, John, 2018
Effect of flavoring chemicals on free radical formation in electronic cigarette aerosols
Free Radical Biology and Medicine, Bitzer, Zachary, Goel, R, Reilly, Samantha, Elias, Ryan J., Silakov, Alexey, Foulds, Jonathan, Muscat, Joshua, Richie, John P., 2018
Effect of ethanol on the solubilization of hydrophobic molecules by sodium caseinate
Food Hydrocolloids, Qu, Yanqi, Harte, Federico M., Elias, Ryan J., Coupland, John N., 2018
Green Tea Polyphenols Mitigate Gliadin-Mediated Inflammation and Permeability in Vitro
Die Nahrung, Van Buiten, Charlene B., Lambert, Joshua, Elias, Ryan J., 2018
Antioxidant activity of a winterized, acetonic rye bran extract containing alkylresorcinols in oil-in-water emulsions
Food Chemistry, Elder, A, Coupland, J, Elias, Ryan, 2018
Impact of fruit-zone leaf removal on rotundone concentration in noiret
American Journal of Enology and Viticulture, Homich, Laura J., Elias, Ryan J., Van Den Heuvel, Justine E., Centinari, Michela, 2017
Brand variation in oxidant production in mainstream cigarette smoke: Carbonyls and free radicals
Food and Chemical Toxicology, Reilly, Samantha M., Goel, Reema, Trushin, Neil, Elias, Ryan J., Foulds, Jonathan, Muscat, Joshua, Liao, Jason, Richie, John P., 2017
Effects of Topography-Related Puff Parameters on Carbonyl Delivery in Mainstream Cigarette Smoke
Chemical Research in Toxicology, Reilly, Samantha, Goel, R, Bitzer, Zachary, Elias, Ryan J., Foulds, Jonathan, Muscat, Joshua, Richie, John P., 2017
Man vs. Machine: A Junior-Level Laboratory Exercise Comparing Human and Instrumental Detection Limits
Journal of Food Science Education, Elias, Ryan J., Hopfer, Helene, Hofstaedter, Amanda N., Hayes, John E., 2017
Removal of fumonisin B1 and B2 from model solutions and red wine using polymeric substances
Food Chemistry, Carrasco-Sánchez, Verónica, Kreitman, Gal Y., Folch-Cano, Christian, Elias, Ryan J., Laurie, V. Felipe, 2017
Binding of Caffeine and Quinine by Whey Protein and the Effect on Bitterness
Journal of Food Science, Tenney, Kelsey, Hayes, John, Euston, Stephen, Elias, Ryan, Coupland, John, 2017
Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo
Nutrition Reports International, Bitzer, Zachary, Wopperer, Amy, Chrisfield, Benjamin, Tao, Ling, Cooper, Timothy, Vanamala, J, Elias, Ryan J., Hayes, John E., Lambert, Joshua D., 2017
Copper(II)-mediated hydrogen sulfide and thiol oxidation to disulfides and organic polysulfanes and their reductive cleavage in wine: Mechanistic elucidation and potential applications
Journal of Agricultural and Food Chemistry, Kreitman, Gal Y., Danilewicz, John C., Jeffery, Davi D.W., Elias, Ryan J., 2017
Variation in Free Radical Yields from U.S. Marketed Cigarettes
Chemical Research in Toxicology, Goel, R, Bitzer, Zachary, Reilly, Samantha, Foulds, J, Trushin, Neil, Muscat, J, Foulds, Jonathan, Muscat, Joshua, Liao, J, Elias, R, Liao, Jason, Richie, J, Elias, Ryan J., Richie, John P., 2017
Effect of ethanol on the solubilization of hydrophobic molecules by sodium caseinate
Food Hydrocolloids, Qu, Y, Harte, F, Elias, Ryan, Coupland, J, 2017
Effects of Solvent and Temperature on Free Radical Formation in Electronic Cigarette Aerosols
Chemical Research in Toxicology, Bitzer, Zachary, Goel, R, Reilly, Samantha, Foulds, J, Foulds, Jonathan, Muscat, J, Muscat, Joshua, Elias, Ryan, Elias, R, Richie, J, Richie, J, 2017
Antioxidants and their mechanisms of action, Elias, Ryan, Decker, E, 2017
Inhibition of gliadin digestion by green tea polyphenols and the potential implications for celiac disease
The FASEB Journal, Van Buiten, C, Lambert, J, Sae-tan, S, Elias, Ryan, 2017
Potential strategies for preventing copper mediated reductive aroma in post-bottle wines
Abstracts of Papers of The American Chemical Society, Elias, Ryan, Kreitman, G, Vernarelli, L, 2017
Rethinking re-stinking: A critical evaluation of hypothesis for formation of sulfurous off aromas during wine storage
Abstracts of Papers of The American Chemical Society, Sacks, G, Kreitman, G, Elias, Ryan, Jeffery, D, 2017
Antioxidants and their mechanisms of action, Elias, Ryan J., Decker, Eric A., 2017
Reaction of Acetaldehyde with Wine Flavonoids in the Presence of Sulfur Dioxide
Journal of Agricultural and Food Chemistry, Sheridan, Marlena K., Elias, Ryan J., 2016
Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis
BMC Complementary and Alternative Medicine, Reddivari, L, Charepalli, V, Radhakrishnan, S, Vadde, R, Elias, R, Lambert, J, Vanamala, Jairam, 2016
Reaction Mechanisms of Metals with Hydrogen Sulfide and Thiols in Model Wine. Part 2: Iron- and Copper-Catalyzed Oxidation
Journal of Agricultural and Food Chemistry, Kreitman, Gal Y., Danilewicz, John C., Jeffery, David W., Elias, Ryan J., 2016
Reaction Mechanisms of Metals with Hydrogen Sulfide and Thiols in Model Wine. Part 1: Copper-Catalyzed Oxidation
Journal of Agricultural and Food Chemistry, Kreitman, Gal Y., Danilewicz, John C., Jeffery, David W., Elias, Ryan J., 2016
(-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss
Die Nahrung, Bitzer, Zachary, Elias, Ryan J., Kumar, M, Vijay-Kumar, Matam, Lambert, Joshua D., 2016
Generation of reactive oxidative species from thermal treatment of sugar solutions
Food Chemistry, Wang, Qingyang, Durand, Erwann, Elias, Ryan J., Tikekar, Rohan V., 2016
Effects of co-inoculation on wine-quality attributes of the high-acid, red hybrid variety chambourcin
American Journal of Enology and Viticulture, Homich, Laura J., Scheinberg, Joshua A., Elias, Ryan J., Gardner, Denise M., 2016
Enhanced phenylpyruvic acid production with Proteus vulgaris by optimizing of the fermentation medium
Acta Alimentaria, Coban, H. B., Demirci, A., Patterson, P. H., Elias, R. J., 2016
Effect of UV-C and pulsed-UV treatments on reduction of Penicillium expansum spores and Escherichia coli K12 in a model apple juice, Ercan, Duygu, Wang, Serena, Demirci, Ali, La Borde, Luke F., Elias, Ryan J., 2016
Enhanced phenylpyruvic acid production with Proteus vulgaris in fed-batch and continuous fermentation
Preparative Biochemistry and Biotechnology, Coban, H, Demirci, Ali, Patterson, Paul, Elias, Ryan J., 2016
Assessing Interactions between Lipophilic and Hydrophilic Antioxidants in Food Emulsions
Journal of Agricultural and Food Chemistry, Durand, Erwann, Zhao, Yu, Coupland, John N., Elias, Ryan J., 2015
Effect of lipophilization on the distribution and reactivity of ingredients in emulsions
Journal of Colloid and Interface Science, Leong, Wai Fun, Berton-Carabin, Claire C., Elias, Ryan J., Lecomte, Jérôme, Villeneuve, Pierre, Zhao, Yu, Coupland, John N., 2015
Highly Reactive Free Radicals in Electronic Cigarette Aerosols
Chemical Research in Toxicology, Goel, Reema, Durand, Erwann, Trushin, Neil, Prokopczyk, Bogdan, Foulds, Jonathan, Elias, Ryan J., Richie, John P., 2015
Effects of dietary Capsicum oleoresin on productivity and immune responses in lactating dairy cows
Journal of Dairy Science, Oh, J., Giallongo, F., Frederick, T., Pate, J., Walusimbi, S., Elias, R. J., Wall, E. H., Bravo, D., Hristov, A. N., 2015
Effect of food structure on the distribution and reactivity of small molecules
Current Opinion in Food Science, Zhao, Yu, Elias, Ryan J., Coupland, John N., 2015
Exogenous acetaldehyde as a tool for modulating wine color and astringency during fermentation
Food Chemistry, Sheridan, Marlena K., Elias, Ryan J., 2015
Enhanced phenylpyruvic acid production with Proteus vulgaris in fed-batch and continuous fermentation
Preparative Biochemistry and Biotechnology, Coban, H, Demirci, A, Patterson, P, Elias, Ryan, 2015
Generation of reactive oxidative species from thermal treatment of sugar solutions.
Food Chemistry, Wang, Q, Durand, E, Elias, Ryan, Tikekar, R, 2015
Dietary soy protein concentrate suppresses colonic inflammation and loss of gut barrier function in vitro and in mice
The FASEB Journal, Lambert, J, Bitzer, Zachary, Wopperer, Amy, Elias, Ryan, 2015
Effect of interfacial properties on the reactivity of a lipophilic ingredient in multilayered emulsions
Food Hydrocolloids, Chaprenet, Jérôme, Berton-Carabin, Claire C., Elias, Ryan J., Coupland, John N., 2014
Screening of phenylpyruvic acid producers and optimization of culture conditions in bench scale bioreactors
Bioprocess and Biosystems Engineering, Coban, H, Demirci, Ali, Patterson, Paul, Elias, Ryan J., 2014
Erratum: Investigation of ethyl radical quenching by phenolics and thiols in model wine (Journal of Agricultural and Food Chemistry (2013) 61:3 (685-692) DOI:10.1021/jf303880g)
Journal of Agricultural and Food Chemistry, Kreitman, Gal Y., Laurie, V. Felipe, Elias, Ryan J., 2014
Influence of cysteine and methionine availability on protein peroxide scavenging activity and phenolic stability in emulsions
Food Chemistry, Zhou, Lisa, Elias, Ryan J., 2014
Enhanced phenylpyruvic acid production with Proteus vulgaris by optimization of fermentation medium
Acta Alimentaria, Coban, H, Demirci, A, Patterson, P, Elias, Ryan, 2014
Hass avocado (Persea americana) seed extract as a natural colorant
Planta Medica, Shegog, RM, Elias, Ryan, Ziegler, GR, Lambert, JD, 2014
Conversion of phenylalanine to phenylpyruvic acid by microbial fermentation, Coban, Hasan B., Demirci, Ali, Patterson, Paul H., Elias, Ryan, 2014