Ryan J. Elias, Ph.D.

Ryan J. Elias, Ph.D.

  • Professor of Food Science
336 Rodney A. Erickson Food Science Building
University Park, PA 16802

Areas of Expertise

  • Food chemistry
  • Enology
  • Wine oxidation
  • Hop chemistry
  • Antioxidants
  • Lipid oxidation

Education

  • Postdoc, Viticulture & Enology, University of California-Davis
  • Ph.D., Food Science, University of Massachusetts-Amherst, 2006
  • B.A., Chemistry, Hamilton College, 2000

Our group studies the free radical chemistry of foods, especially as it relates to understanding antioxidant and pro-oxidant mechanisms.  Current research projects in our laboratory are in the following areas:

  • Oxidative stability of wine and beer components
  • Lipid oxidation in complex foods
  • Use of electron paramagnetic resonance (EPR) to investigate free radical mechanisms in foods, tobacco products, and biological systems
  • Small molecule partitioning in complex foods using EPR spin probes
  • Redox chemistry and stability of polyphenols in foods


Honors and Awards

  • Outstanding Collaborative Research Award, Penn State College of Medicine, 2018
  • Community of Teaching Award, Penn State College of Agricultural Sciences, 2018
  • Anna and Guy Bixler Memorial Teaching Award in Food Science, 2015
  • Young Scientist Award, American Chemical Society, Agricultural and Food Chemistry Division, 2012
  • Honored Student Award, American Oil Chemists' Society, 2005


Funding

Work in our group is, or has been, supported by the following agencies and organizations:

  • Agriculture and Food Research Initiative, US Department of Agriculture (USDA)
  • Specialty Crop Research Initiative, US Department of Agriculture (USDA)
  • Tobacco Centers of Regulatory Science (P50), US National Institutes of Health (NIH) and US Food and Drug Administration (FDA)
  • Northeast Sustainable Agriculture Research and Education, US Department of Agriculture (USDA)
  • Pennsylvania Wine Marketing and Research Board, Pennsylvania Department of Agriculture (PDA)
  • Pennsylvania Malt and Brewed Beverage Industry Promotion Board, Pennsylvania Department of Agriculture (PDA)
  • Dairy Management Inc. (DMI)

Selected Publications

Google Scholar publication list here

NIH/NCBI MyBibliography here

Publications

Impact of copper fungicide use in hop production on the total metal content and stability of wort and dry-hopped beer
MDPI Beverages, Chrisfield, B, Hopfer, Helene, Elias, Ryan, 2020

Impact of electronic cigarette heating coil resistance on the production of reactive carbonyls, reactive oxygen species and induction of cytotoxicity in human lung cancer cells in vitro
Regulatory Toxicology and Pharmacology, Cirillo, Silvia, Urena, Jose F., Lambert, Joshua D., Vivarelli, Fabio, Canistro, Donatella, Paolini, Moreno, Cardenia, Vladimiro, Rodriguez-Estrada, Maria Teresa, Richie, John P., Elias, Ryan J., 2019

Modeling the Impacts of Weather and Cultural Factors on Rotundone Concentration in Cool-Climate Noiret Wine Grapes
Frontiers in Plant Science, Harner, Andrew D., Vanden Heuvel, Justine E., Marini, Richard P., Elias, Ryan J., Centinari, Michela, 2019

UV-C irradiated gallic acid exhibits enhanced antimicrobial activity via generation of reactive oxidative species and quinone
Food Chemistry, Wang, Qingyang, Leong, Wai Fun, Elias, Ryan, Tikekar, Rohan V., 2019

Physicochemical interactions with (-)-epigallocatechin-3-gallate drive structural modification of celiac-associated peptide α2-gliadin (57-89) at physiological conditions
Food and Function, Van Buiten, Charlene B., Yennawar, Neela H., Pacheco, Carlos N., Hatzakis, Emmanuel, Elias, Ryan J., 2019

Antioxidant activity of a winterized, acetonic rye bran extract containing alkylresorcinols in oil-in-water emulsions
Food Chemistry, Elder, Andrew S., Coupland, John Neil, Elias, Ryan, 2019

Effect of very low nicotine cigarettes on puff topography: Results of a take-home topography device study
Tobacco Regulatory Science, Reilly, S, Stennett, A, Goel, R, Bitzer, Z, Elias, Ryan, Reinhart, L, Wasserman, E, Foulds, Jonathan, Muscat, Joshua, Richie, John, 2019

In Vitro Antioxidant and Cancer Inhibitory Activity of a Colored Avocado Seed Extract
International Journal of Food Science, Dabas, Deepti, Elias, Ryan J., Ziegler, Gregory R., Lambert, Joshua D., 2019

Loss and formation of malodorous volatile sulfhydryl compounds during wine storage
Critical Reviews in Food Science and Nutrition, Kreitman, G, Elias, Ryan, Jeffery, J, Sacks, G, 2019

Effects of charcoal on carbonyl delivery from commercial, research, and make­-your­-own cigarettes
Chemical Research in Toxicology, Reilly, S, Goel, Reema, Trushin, Neil, Bitzer, Z, Elias, Ryan, Muscat, Joshua, Richie, John, 2019

Effects of Charcoal on Carbonyl Delivery from Commercial, Research, and Make-Your-Own Cigarettes
Chemical Research in Toxicology, Reilly, Samantha M., Goel, Reema, Trushin, Neil, Bitzer, Zachary T., Elias, Ryan, Muscat, Joshua, Richie, John, 2018

Inclusion complex formation between high amylose corn starch and alkylresorcinols from rye bran
Food Chemistry, Gunenc, Aynur, Kong, Lingyan, Elias, Ryan, Ziegler, Gregory Ray, 2018

Characterization of amylose inclusion complexes using electron paramagnetic resonance spectroscopy
Food Hydrocolloids, Kong, Lingyan, Yucel, Umut, Yoksan, Rangrong, Elias, Ryan, Ziegler, Gregory Ray, 2018

Effect of Charcoal in Cigarette Filters on Free Radicals in Mainstream Smoke
Chemical Research in Toxicology, Goel, Reema, Bitzer, Zachary T., Reilly, Samantha M., Bhangu, Gurkirat, Trushin, Neil, Elias, Ryan, Foulds, Jonathan, Muscat, Joshua, Richie, John, 2018

Little cigars, filtered cigars, and their carbonyl delivery relative to cigarettes
Nicotine and Tobacco Research, Reilly, Samantha M., Goel, Reema, Bitzer, Zachary, Elias, Ryan, Foulds, Jonathan, Muscat, Joshua, Richie, John, 2018

Impact of roasting on the flavan-3-ol composition, sensory-related chemistry, and in vitro pancreatic lipase inhibitory activity of cocoa beans
Food Chemistry, Stanley, Todd H., Van Buiten, Charlene B., Baker, Scott A., Elias, Ryan, Anantheswaran, Ramaswamy C., Lambert, Joshua D., 2018

Green Tea Polyphenols Mitigate Gliadin-Mediated Inflammation and Permeability in Vitro
Molecular Nutrition and Food Research, Van Buiten, Charlene B., Lambert, Joshua D., Elias, Ryan, 2018

Influence of Smoking Puff Parameters and Tobacco Varieties on Free Radicals Yields in Cigarette Mainstream Smoke
Chemical Research in Toxicology, Goel, Reema, Bitzer, Zachary T., Reilly, Samantha M., Foulds, Jonathan, Muscat, Joshua, Elias, Ryan, Richie, John, 2018

Effect of flavoring chemicals on free radical formation in electronic cigarette aerosols
Free Radical Biology and Medicine, Bitzer, Zachary T., Goel, Reema, Reilly, Samantha M., Elias, Ryan, Silakov, Alexey, Foulds, Jonathan, Muscat, Joshua, Richie, John, 2018

Effect of ethanol on the solubilization of hydrophobic molecules by sodium caseinate
Food Hydrocolloids, Qu, Yanqi, Harte, Federico M., Elias, Ryan J., Coupland, John N., 2018

Effects of Solvent and Temperature on Free Radical Formation in Electronic Cigarette Aerosols
Chemical Research in Toxicology, Bitzer, Zachary T., Goel, Reema, Reilly, Samantha M., Foulds, Jonathan, Muscat, Joshua, Elias, Ryan, Richie, John, 2018

Antioxidant activity of a winterized, acetonic rye bran extract containing alkylresorcinols in oil-in-water emulsions
Food Chemistry, Elder, A, Coupland, John, Elias, Ryan, 2018

Impact of fruit-zone leaf removal on rotundone concentration in noiret
American Journal of Enology and Viticulture, Homich, Laura J., Elias, Ryan J., Van Den Heuvel, Justine E., Centinari, Michela, 2017

Brand variation in oxidant production in mainstream cigarette smoke
Food and Chemical Toxicology, Reilly, Samantha M., Goel, Reema, Trushin, Neil, Elias, Ryan J., Foulds, Jonathan, Muscat, Joshua, Liao, Jason, Richie, John P., 2017

Effects of Topography-Related Puff Parameters on Carbonyl Delivery in Mainstream Cigarette Smoke
Chemical Research in Toxicology, Reilly, Samantha M., Goel, Reema, Bitzer, Zachary, Elias, Ryan, Foulds, Jonathan, Muscat, Joshua, Richie, John, 2017

Man vs. Machine
Journal of Food Science Education, Elias, Ryan, Hopfer, Helene, Hofstaedter, Amanda N., Hayes, John E., 2017

Removal of fumonisin B1 and B2 from model solutions and red wine using polymeric substances
Food Chemistry, Carrasco-Sánchez, Verónica, Kreitman, Gal Y., Folch-Cano, Christian, Elias, Ryan J., Laurie, V. Felipe, 2017

Variation in Free Radical Yields from U.S. Marketed Cigarettes
Chemical research in toxicology, Goel, Reema, Bitzer, Zachary, Reilly, Samantha M., Trushin, Neil, Foulds, Jonathan, Muscat, Joshua, Liao, Jason, Elias, Ryan J., Richie, John P., 2017

Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo
Journal of Nutritional Biochemistry, Bitzer, Zachary T., Wopperer, Amy L., Chrisfield, Benjamin J., Tao, Ling, Cooper, Timothy K., Vanamala, Jairam, Elias, Ryan J., Hayes, John E., Lambert, Joshua D., 2017

Effect of ethanol on the solubilization of hydrophobic molecules by sodium caseinate
Food Hydrocolloids, Qu, Y, Harte, Federico, Elias, Ryan, Coupland, John, 2017

Copper(II)-mediated hydrogen sulfide and thiol oxidation to disulfides and organic polysulfanes and their reductive cleavage in wine
Journal of agricultural and food chemistry, Kreitman, Gal Y., Danilewicz, John C., Jeffery, Davi D.W., Elias, Ryan, 2017

Effects of solvent and temperature on free radical formation in electronic cigarette aerosols
Chemical Research in Toxicology, Bitzer, Z, Goel, R, Foulds, Jonathan, Muscat, Joshua, Elias, Ryan, Richie, John, 2017

Mitigation of colitis and loss of gut barrier function by soy protein concentrate: a potential role for the inflammasome
J Nutr Biochem, Bitzer, Zachary, Wopperer, Amy, Tao, Ling, Cooper, Timothy, Vanamala, Jairam, Elias, Ryan, Lambert, Joshua, 2017

Reaction of Acetaldehyde with Wine Flavonoids in the Presence of Sulfur Dioxide
Journal of agricultural and food chemistry, Sheridan, Marlena K., Elias, Ryan J., 2016

(-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss
Molecular Nutrition and Food Research, Bitzer, Zachary T., Elias, Ryan, Kumar, Matam Vijay, Lambert, Joshua D., 2016

Reaction Mechanisms of Metals with Hydrogen Sulfide and Thiols in Model Wine. Part 1
Journal of agricultural and food chemistry, Kreitman, Gal Y., Danilewicz, John C., Jeffery, David W., Elias, Ryan J., 2016

Reaction Mechanisms of Metals with Hydrogen Sulfide and Thiols in Model Wine. Part 2
Journal of Agricultural and Food Chemistry, Kreitman, Gal Y., Danilewicz, John C., Jeffery, David W., Elias, Ryan, 2016

Effects of co-inoculation on wine-quality attributes of the high-acid, red hybrid variety chambourcin
American Journal of Enology and Viticulture, Homich, Laura J., Scheinberg, Joshua A., Elias, Ryan, Gardner, Denise M., 2016

Generation of reactive oxidative species from thermal treatment of sugar solutions
Food Chemistry, Wang, Qingyang, Durand, Erwann, Elias, Ryan, Tikekar, Rohan V., 2016

Enhanced phenylpyruvic acid production with Proteus vulgaris by optimizing of the fermentation medium
Acta Alimentaria, Coban, H. B., Demirci, A., Patterson, P. H., Elias, R. J., 2016

Enhanced phenylpyruvic acid production with Proteus vulgaris in fed-batch and continuous fermentation
Preparative Biochemistry and Biotechnology, Coban, Hasan B., Demirci, Ali, Patterson, Paul H., Elias, Ryan, 2016

Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis
BMC complementary and alternative medicine, Reddivari, Lavanya, Charepalli, Venkata, Radhakrishnan, Sridhar, Vadde, Ramakrishna, Elias, Ryan J., Lambert, Joshua D., Vanamala, Jairam K.P., 2016

Assessing Interactions between Lipophilic and Hydrophilic Antioxidants in Food Emulsions
Journal of agricultural and food chemistry, Durand, Erwann, Zhao, Yu, Coupland, John Neil, Elias, Ryan, 2015

Effect of lipophilization on the distribution and reactivity of ingredients in emulsions
Journal of Colloid And Interface Science, Leong, Wai Fun, Berton-Carabin, Claire C., Elias, Ryan, Lecomte, Jérôme, Villeneuve, Pierre, Zhao, Yu, Coupland, John Neil, 2015

Highly Reactive Free Radicals in Electronic Cigarette Aerosols
Chemical Research in Toxicology, Goel, Reema, Durand, Erwann, Trushin, Neil, Prokopczyk, Bogdan, Foulds, Jonathan, Elias, Ryan J., Richie, John P., 2015

Exogenous acetaldehyde as a tool for modulating wine color and astringency during fermentation
Food Chemistry, Sheridan, Marlena K., Elias, Ryan, 2015

Enhanced phenylpyruvic acid production with Proteus vulgaris in fed-batch and continuous fermentation
Preparative Biochemistry and Biotechnology, Coban, H, Demirci, Ali, Patterson, Paul, Elias, Ryan, 2015

Generation of reactive oxidative species from thermal treatment of sugar solutions.
Food Chemistry, Wang, Q, Durand, E, Elias, Ryan, Tikekar, R, 2015

Effect of interfacial properties on the reactivity of a lipophilic ingredient in multilayered emulsions
Food Hydrocolloids, Chaprenet, Jérôme, Berton-Carabin, Claire C., Elias, Ryan J., Coupland, John N., 2014

Screening of phenylpyruvic acid producers and optimization of culture conditions in bench scale bioreactors
Bioprocess and biosystems engineering, Coban, Hasan B., Demirci, Ali, Patterson, Paul H., Elias, Ryan J., 2014

Influence of cysteine and methionine availability on protein peroxide scavenging activity and phenolic stability in emulsions
Food Chemistry, Zhou, Lisa, Elias, Ryan J., 2014

Enhanced phenylpyruvic acid production with Proteus vulgaris by optimization of fermentation medium
Acta Alimentaria, Coban, H, Demirci, A, Patterson, P, Elias, Ryan, 2014

Immune and production responses of dairy cows to postruminal supplementation with phytonutrients
Journal of dairy science, Oh, J., Hristov, A. N., Lee, C., Cassidy, T., Heyler, K., Varga, G. A., Pate, J., Walusimbi, S., Brzezicka, E., Toyokawa, K., Werner, J., Donkin, S. S., Elias, R., Dowd, S., Bravo, D., 2013

Effect of metal chelators on the oxidative stability of model wine
Journal of agricultural and food chemistry, Kreitman, Gal Y., Cantu, Annegret, Waterhouse, Andrew L., Elias, Ryan J., 2013

Effect of the lipophilicity of model ingredients on their location and reactivity in emulsions and solid lipid nanoparticles
Colloids and Surfaces A: Physicochemical and Engineering Aspects, Berton-Carabin, Claire C., Coupland, John N., Elias, Ryan J., 2013

Antioxidant and pro-oxidant activity of (-)-epigallocatechin-3-gallate in food emulsions
Food Chemistry, Zhou, Lisa, Elias, Ryan, 2013

Effect of liquid oil on the distribution and reactivity of a hydrophobic solute in solid lipid nanoparticles
JAOCS, Journal of the American Oil Chemists' Society, Yucel, Umut, Elias, Ryan, Coupland, John Neil, 2013

Enzyme triggered release of aroma molecules from oil-in-water emulsions
Colloids and Surfaces A: Physicochemical and Engineering Aspects, Wong, Rebecca C., Elias, Ryan, Lambert, Joshua D., Relkin, Perla, Coupland, John Neil, 2013

Localization and reactivity of a hydrophobic solute in lecithin and caseinate stabilized solid lipid nanoparticles and nanoemulsions
Journal of Colloid And Interface Science, Yucel, Umut, Elias, Ryan, Coupland, John Neil, 2013

Reactivity of a model lipophilic ingredient in surfactant-stabilized emulsions
Colloids and Surfaces A: Physicochemical and Engineering Aspects, Berton-Carabin, Claire C., Elias, Ryan, Coupland, John Neil, 2013

Investigation of ethyl radical quenching by phenolics and thiols in model wine
Journal of agricultural and food chemistry, Kreitman, Gal Y., Laurie, V. Felipe, Elias, Ryan J., 2013

Generation of potentially bioactive ergosterol-derived products following pulsed ultraviolet light exposure of mushrooms (Agaricus bisporus)
Food Chemistry, Kalaras, Michael D., Beelman, Robert B., Holick, Michael F., Elias, Ryan J., 2012

Influence of endogenous ferulic acid in whole wheat flour on bread crust aroma
Journal of agricultural and food chemistry, Moskowitz, Marlene R., Bin, Qing, Elias, Ryan, Peterson, Devin G., 2012

Oxidative stability of (-)-epigallocatechin gallate in the presence of thiols
Journal of agricultural and food chemistry, Unnadkat, Nausheel R., Elias, Ryan J., 2012

Reactivity of a lipophilic ingredient solubilized in anionic or cationic surfactant micelles
Colloids and Surfaces A: Physicochemical and Engineering Aspects, Berton-Carabin, Claire C., Coupland, John N., Qian, Cheng, McClements, D. Julian, Elias, Ryan J., 2012

Influence of phenolic compounds on the mechanisms of pyrazinium radical generation in the maillard reaction
Journal of Agricultural and Food Chemistry, Bin, Qing, Peterson, Devin G., Elias, Ryan, 2012

Factors influencing the antioxidant and pro-oxidant activity of polyphenols in oil-in-water emulsions
Journal of Agricultural and Food Chemistry, Zhou, Lisa, Elias, Ryan, 2012

Effects of postharvest pulsed uv light treatment of white button mushrooms (Agaricus bisporus) on vitamin D2 content and quality attributes
Journal of Agricultural and Food Chemistry, Kalaras, Michael D., Beelman, Robert B., Elias, Ryan, 2012

Investigating the hydrogen peroxide quenching capacity of proteins in polyphenol-rich foods
Journal of Agricultural and Food Chemistry, Zhou, Lisa, Elias, Ryan, 2011

Controlling the fenton reaction in wine
Journal of agricultural and food chemistry, Elias, Ryan J., Waterhouse, Andrew L., 2010