Yi Zhang, Ph.D.

Yi Zhang, Ph.D.

  • Frederik Sr. and Faith E. Rasmussen Career Development Professor in Food Science
  • Assistant Professor of Food Science
405 Rodney Erickson Food Science Building
UNIVERSITY PARK, PA 16802

Areas of Expertise

  • Food Protein Innovation
  • Enzyme Discovery
  • Protein Design & Generative AI
  • Sustainable Bioprocessing & Upcycling
  • Food Biochemistry

Education

  • Ph.D., Food Science & Agricultural Chemistry, McGill University, Canada
  • M.Sc., Food Science, Ocean University of China, China
  • B.Sc., Food Science & Engineering, Ocean University of China, China

Previous Appointments

  • Assistant professor & Junior chair, French National Center for Scientific Research, France
  • Postdoctoral scholar, McGill University, Canada

Courses

  • FDSC 410: Food Chemistry and Analysis II (Spring semester)
  • FDSC 201: Introductory Food Science Practicum (Fall semester)
  • FDSC 496: Independent Studies (all semesters)
  • FDSC 596: Individual Studies (all semesters)
  • FDSC 600: Thesis Research (all semesters)

Publications

Tyrosinase Recovered from White Button Mushroom Waste: Extraction, Characterization, and Application in Casein Cross-Linking
Journal of Agricultural and Food Chemistry, Tran, Trang Thuy, Xu, Zhe, Coupland, John, Zhang, Yi, 2026

Poly(sodium acrylate-co-acrylamide) hydrogel beads as selective enhancement platforms for biomarker detection in tear fluid
Chemical Engineering Journal Advances, Li, Jilong, Lecoester, Melanie, None, Bartos, Andras, Zhang, Yi, Nardin, Corinne, Vancso, Gyula, 2025

Soluble recombinant transglutaminase for crosslinking plant protein hydrolysates
Food Chemistry, Liu, Han, Nardin, Corinne, Zhang, Yi, 2025

Formation of pea protein fibrils via novel trypsin-assisted self-assembling process
Food Hydrocolloids, Zhang, Wenxue, Wang, Ke, Zhang, Yi, 2025

Core-shell gelatin-chitosan nanoparticles with lysozyme responsiveness formed via pH-drive and transglutaminase cross-linking
International Journal of Biological Macromolecules, Li, Jilong, Zhao, Yongqiang, Zhang, Yi, Nardin, Corinne, 2025

A new cold-active transglutaminase: Discovery, computational insights, and recombinant expression
Enzyme and Microbial Technology, Liu, Han, Ding, Saisai, Nardin, Corinne, Zhang, Yi, 2025

An Updated Review on Soy Antioxidant Peptides (SAPs): Molecular Mechanisms, High-Tech Generation Pipeline, Industrial Production Strategies, and New Product Innovation
Food Reviews International, Zhang, Rong, He, Shudong, Di, Dakai, Li, Huimei, Qiu, Min, Wu, Zeyu, Sun, Hanju, Zhang, Yi, 2025

Functional bioplastic films from cocoa shell cellulose and natural waxes: Toward sustainable active packaging
Food Packaging and Shelf Life, Qamar, Sarmad, Piccolella, Simona, Ziegler, Gregory, Pacifico, Severina, Zhang, Yi, 2025

Bioactive Peptides Derived from Tuna: Screening, Extraction, Bioactivity, and Mechanism of Action
Marine Drugs, Cheng, Jing-an, Wang, Di, Yu, Gang, Chen, Shengjun, Ma, Zhenhua, Wei, Ya, Zhao, Xue, Li, Chunsheng, Wang, Yueqi, Zhang, Yi, Cap, R, Zhao, Yongqiang, 2025

csi-miR166e, A microribonucleic acid of considerable abundance in plant food, ameliorates high-fat diet/streptozotocin-induced type 2 diabetes in mice via oral administration
Journal of Agricultural and Food Chemistry, Li, Ying, Xu, Qin, Wang, Jianing, Xin, Yirao, Zhang, Yi, Qin, Xinshu, Xu, Ke, Yang, Xingbin, Wang, Xingyu, 2025

Bioplastic films from cassava peels: Enzymatic transformation and film properties
Industrial Crops and Products, Zhang, Yi, Xie, Jiayu, Ellis, William O., Li, Jilong, Appaw, William Ofori, Simpson, Benjamin K., 2024

Food-grade gelatin from camel skin: Extraction, characterisation and potential use for thin film packaging preparation
Food Hydrocolloids, Hajlaoui, Kamel, Abdelhedi, Ola, Salem, Ali, Debeaufort, Frederic, Zouari, Nacim, Zhang, Yi, Jridi, Mourad, 2024

Atypical Plant miRNA cal-miR2911: Robust Stability against Food Digestion and Specific Promoting Effect on Bifidobacterium in Mice
Journal of Agricultural and Food Chemistry, Xu, Qin, Wang, Jianing, Zhang, Yi, Li, Ying, Qin, Xinshu, Xin, Yirao, Li, Yinglei, Xu, Ke, Yang, Xingbin, Wang, Xingyu, 2024

Transglutaminase: Fundamentals and Applications, Zhang, Yi, Simpson, Benjamin, 2024

Endogenous enzymes, Ghosh, Ishita, Liu, Han, Simpson, Benjamin, Zhang, Yi, 2024

Enzymes from fish processing waste materials and their commercial applications, Klomklao, Sappasith, Kuepethkaew, Sakonwat, Benjakul, Soottawat, Zhang, Yi, Simpson, Benjamin, 2024

Enzymes in food processing: Present uses and future prospects, Zhang, Yi, Li, Jilong, Nardin, Corinne, Villalonga, Reynaldo, Simpson, Benjamin, 2024

Novel chymotrypsin purified and biochemically characterized from digestive organs of bigfin reef squid (Sepioteuthis lessoniana)
Resources, Satjarak, Jirapan, Klomklao, Sappasith, Zhang, Yi, Thongprajukaew, Karun, 2024

osa-miR168a, a plant miRNA that survives the process of in vivo food digestion, attenuates dextran sulfate sodium-induced colitis in mice by oral administration
Journal of Agricultural and Food Chemistry, Xu, Qin, Li, Ying, Qin, Xinshu, Xin, Yirao, Wang, Jianing, Zhang, Yi, Xu, Ke, Yang, Xingbin, Wang, Xingyu, 2024

Visualized detection of goat milk adulteration using golden nanoparticles (AuNPs) and the dilution sensitive-PCR based on supercoiled plasmids and dUTP incorporation
Journal of Food Composition and Analysis, Li, Ying, Li, Yinglei, Wang, Jianing, Zhang, Yi, Xu, Qin, Qin, Xinshu, Xin, Yirao, Xu, Ke, Yang, Xingbin, Wang, Xingyu, 2024

Exploring the allergenic potential of sesame oleosins: Isolation and bioinformatics analysis
International Journal of Biological Macromolecules, He, Shudong, Gao, Kuan, Pan, Tiange, Wu, Yanni, Di, Dakai, Li, Xingjiang, Sun, Hanju, Zhang, Yi, 2024

Transglutaminase, Zhang, Yi, Simpson, Benjamin K., 2024

An introduction to transglutaminases, Zhang, Yi, Parthasarathy, Srividya, Simpson, Benjamin K., 2024

Newly engineered transglutaminases, Liu, Han, Ghosh, Ishita, Nardin, Corinne, Zhang, Yi, 2024

Extraction and characterization of new biocompatible gelatin from camel slaughter by-products: biochemical, sensory, interfacial, and textural properties
Euro-Mediterranean Journal for Environmental Integration, Ouechtati, Chaima, Abdelhedi, Ola, Zhang, Yi, Nardin, Corinne, Zouari, Nacim, Jridi, Mourad, 2024

Characteristics of gelatin from lizardfish (Saurida micropectoralis) and threadfin bream (Nemipterus hexodon) skins as influenced by extraction conditions
Journal of Food Science and Technology, Kuepethkaew, Sakonwat, Klomklao, Sappasith, Zhang, Yi, Aryee, Alberta N.A., Benjakul, Soottawat, Betti, Mirko, Simpson, Benjamin K., 2023

In-Vitro Screenings for Biological and Antioxidant Activities of Aqueous Extract from Sacha Inchi (Plukenetia volubilis L.) Husks
Walailak Journal of Science and Technology, Thuanthong, Arthittaya, Klomklao, Sappasith, Panyo, Jarurat, Zhang, Yi, 2023

Plant miRNA bol-miR159 Regulates Gut Microbiota Composition in Mice: In Vivo Evidence of the Crosstalk between Plant miRNAs and Intestinal Microbes
Journal of Agricultural and Food Chemistry, Xu, Qin, Qin, Xinshu, Zhang, Yi, Xu, Ke, Li, Ying, Li, Yinglei, Qi, Bangran, Li, Yan, Yang, Xingbin, Wang, Xingyu, 2023

Lycium ruthenicum Murr. anthocyanins inhibit hyperproliferation of synovial fibroblasts from rheumatoid patients and the mechanism study powered by network pharmacology
Phytomedicine, Xu, Ke, Qin, Xinshu, Zhang, Yi, Yang, Mingyi, Zheng, Haishi, Li, Yinglei, Yang, Xingbin, Xu, Qin, Li, Ying, Xu, Peng, Wang, Xingyu, 2023

Hypoglycemic effect of polysaccharides of Dendrobium officinale compound on type 2 diabetic mice
Journal of Functional Foods, Li, Chen, Wang, Yunwei, Huang, Zijia, Zhang, Yi, Li, Jiao, Zhang, Qing, Simpson, Benjamin Kofi, Wang, Jingxue, 2023

Interactive effect of hot air roasting processes on the sensory property, allergenicity, and oil extraction of sesame (Sesamum indicum L.) seeds
Grain and Oil Science and Technology, He, Shudong, Pan, Tiange, Zhang, Zuoyong, Wu, Yanni, Sun, Hanju, Ma, Youshui, Zhang, Yi, 2023

Pectin from plantain peels: Green recovery for transformation into reinforced packaging films
Waste Management, Xie, Jiayu, Zhang, Yi, Klomklao, Sappasith, Simpson, Benjamin K., 2023

Quantitative analysis of miRNAs using SplintR ligase-mediated ligation of complementary-pairing probes enhanced by RNase H (SPLICER)-qPCR
Molecular Therapy Nucleic Acids, Qin, Xinshu, Wang, Xingyu, Xu, Ke, Zhang, Yi, Tian, Hongye, Li, Yinglei, Qi, Bangran, Yang, Xingbin, 2023

Assessment of dynamic digestion fate of soy protein gel induced by lactic acid bacteria: A protein digestomics research
Food Hydrocolloids, Wang, Yaqiong, Sun, Wenjing, Zhang, Yi, Li, Wei, Zhang, Qiuqin, Rui, Xin, 2023

A Comparative Study on Extraction and Physicochemical Properties of Soluble Dietary Fiber from Glutinous Rice Bran Using Different Methods
Separations, Chen, Haoshuang, He, Shudong, Sun, Hanju, Li, Qiuyang, Gao, Kuan, Miao, Xinya, Xiang, Jie, Wu, Xiongjie, Gao, Longmei, Zhang, Yi, 2023

Editorial: Rising stars in nutrition and food science technology: innovative research on nutritional marine foods
Frontiers in Nutrition, Wang, Yueqi, Zhang, Yi, Zhao, Yongqiang, Liang, Peng, 2023

Recent advances in the effects of protein oxidation on aquatic products quality: mechanism and regulation
International Journal of Food Science and Technology, Yu, Ye, Zhao, Yongqiang, Zhang, Yi, Simpson, Benjamin K., Chen, Shengjun, Wang, Yueqi, Li, Chunsheng, Wang, Di, Pan, Chuang, 2023

Comprehensive biorefinery of invasive European green crab (Carcinus maenas) into multiple high-value biomolecules
Journal of Cleaner Production, Zhang, Yi, Sully, Paola, Spitzer, Lea, Dutilleul, Pierre, Simpson, Benjamin K., 2022

Thai traditional fermented fish paste Ka-pi-plaa: Chemical compositions and physical properties
Journal of Food Processing and Preservation, Sripokar, Pakteera, Klomklao, Sappasith, Zhang, Yi, Hansen, Egon Bech, Maneerat, Suppasil, Panyo, Jarurat, 2022

Digestion of Plant Dietary miRNAs Starts in the Mouth under the Protection of Coingested Food Components and Plant-Derived Exosome-like Nanoparticles
Journal of Agricultural and Food Chemistry, Qin, Xinshu, Wang, Xingyu, Xu, Ke, Zhang, Yi, Ren, Xiaoyu, Qi, Bangran, Liang, Qian, Yang, Xingbin, Li, Lin, Li, Shiqi, 2022

Editorial overview: Food bioprocessing
Current Opinion in Food Science, Zhang, Yi, Simpson, Benjamin K., 2022

Seal meat enzymatic hydrolysates and its digests: A comparison on protein and minerals profiles
LWT, Zhang, Yi, Rui, Xin, Vaugeois, Romy, Simpson, Benjamin K., 2022

Evaluation of the Preservation and Digestion of Seal Meat Processed with Heating and Antioxidant Seal Meat Hydrolysates
Marine Drugs, Zhang, Yi, Spitzer, Lea, Rui, Xin, Fernandes, Susana C.M., Vaugeois, Romy, Simpson, Benjamin K., 2022

Prediction and characterization of the T cell epitopes for the major soybean protein allergens using bioinformatics approaches
Proteins: Structure, Function and Genetics, Zhou, Fanlin, He, Shudong, Zhang, Yi, Wang, Yongfei, Sun, Hanju, Liu, Qian, 2022

Ka-pi-plaa fermented using beardless barb fish: physicochemical, microbiological and antioxidant properties as influenced by production processes
International Journal of Food Science and Technology, Sripokar, Pakteera, Hansen, Egon Bech, Zhang, Yi, Maneerat, Suppasil, Klomklao, Sappasith, 2022

Food enzymes immobilization: novel carriers, techniques and applications
Current Opinion in Food Science, Xie, Jiayu, Zhang, Yi, Simpson, Benjamin, 2022

Progresses and future prospects in biodegradation of marine biopolymers and emerging biopolymer-based materials for sustainable marine ecosystems
Green Chemistry, Samalens, François, Thomas, Martin, Claverie, Marion, Castejon, Natalia, Zhang, Yi, Pigot, Thierry, Blanc, Sylvie, Fernandes, Susana, 2022

Oxidative stress suppression in: C. elegans by peptides from dogfish skin via regulation of transcription factors DAF-16 and HSF-1
Food and Function, Ma, Xiaoli, Li, Jiao, Zhang, Yi, Hacariz, Orcun, Xia, Jianguo, Simpson, Benjamin K., Wang, Zhuanhua, 2022

Enzymological characteristics of pepsinogens and pepsins purified from lizardfish (Saurida micropectoralis) stomach
Food Chemistry, Kuepethkaew, Sakonwat, Zhang, Yi, Kishimura, Hideki, Kumagai, Yuya, Simpson, Benjamin K., Benjakul, Soottawat, Damodaran, Srinivasan, Klomklao, Sappasith, 2022

Cold setting of gelatin–antioxidant peptides composite hydrogels using a new psychrophilic recombinant transglutaminase (rTGase)
Food Hydrocolloids, Zhang, Yi, Li, Chen, Geary, Timothy, Jardim, Armando, He, Shudong, Simpson, Benjamin K., 2022

Autolysis and the endogenous proteinases characterised in beardless barb (Anematichthys apogon) muscle
International Journal of Food Science and Technology, Sripokar, Pakteera, Zhang, Yi, Simpson, Benjamin K., Hansen, Egon Bech, Maneerat, Suppasil, Klomklao, Sappasith, 2021

Comparison of crude prolamins from seven kidney beans (Phaseolus vulgaris L.) based on composition, structure and functionality
Food Chemistry, Yang, Yufei, He, Shudong, Zhang, Yi, Li, Xingjiang, Liu, Haiyan, Li, Qiming, Cao, Xiaodong, Ye, Yongkang, Sun, Hanju, 2021

Antioxidant Properties of Sacha Inchi (Plukenetia volubilis) Shell Extracts as Affected by Solvents used for Prior Decolorization
ASEAN Journal of Scientific and Technological Reports, Thuanthong, Arthittaya, Patchimpet, Jaran, Visessanguan, Wonnop, Panyo, Jarurat, Benjakul, Soottawat, Zhang, Yi, Klomklao, Sappasith, 2021

Indigenous milk enzymes, Zhang, Yi, Simpson, Benjamin, Adi, Doreen, Sampson, Gilbert, Li, Chen, 2021

Effects of Low-pH Treatment on the Allergenicity Reduction of Black Turtle Bean (Phaseolus vulgaris L.) Lectin and Its Mechanism
Journal of Agricultural and Food Chemistry, He, Shudong, Zhao, Jinlong, Zhang, Yi, Zhu, Yuchen, Li, Xingjiang, Cao, Xiaodong, Ye, Yongkang, Li, Jing, Sun, Hanju, 2021

Trends in nanozymes development versus traditional enzymes in food science
Current Opinion in Food Science, Zhang, Yi, Rui, Xin, Simpson, Benjamin K., 2021

Ultrasonic enhancement of lipase-catalyzed transesterification for biodiesel production from used cooking oil
Biomass Conversion and Biorefinery, Patchimpet, Jaran, Zhang, Yi, Simpson, Benjamin K., Rui, Xin, Sangkharak, Kanokphorn, Eiad-ua, Apiluck, Klomklao, Sappasith, 2021

Advances in epitope mapping technologies for food protein allergens: A review
Trends in Food Science and Technology, Zhou, Fanlin, He, Shudong, Sun, Hanju, Wang, Yongfei, Zhang, Yi, 2021

Food-related transglutaminase obtained from fish/shellfish
Critical Reviews in Food Science and Nutrition, Zhang, Yi, Simpson, Benjamin K., 2020

Contribution of Special Structural Features to High Thermal Stability of a Cold-Active Transglutaminase
Journal of Agricultural and Food Chemistry, Zhang, Yi, Li, Chen, Geary, Timothy, Simpson, Benjamin Kofi, 2020

Comparison of physicochemical properties of recombinant buckwheat trypsin inhibitor (rBTI) and soybean trypsin inhibitor (SBTI)
Protein Expression and Purification, Li, Chen, Li, Wenjie, Zhang, Yi, Simpson, Benjamin Kofi, 2020

Effect of three kinds of natural preservative cocktails on vacuum-packed chilled pork
Food Science and Nutrition, Li, Chen, Han, Yuhang, Fan, Sanhong, Ma, Lizhen, Zhang, Yi, Simpson, Benjamin Kofi, 2020

Current role of in silico approaches for food enzymes
Current Opinion in Food Science, Zhang, Yi, Aryee, Alberta NA, Simpson, Benjamin K., 2020

Microbial enzymes from fish processing discards, Zhang, Yi, Gohou, Hanny M., Klomklao, Sappasith, Simpson, Benjamin K., 2019

An introduction to agricultural and fishery wastes, Zhang, Yi, Zhang, Jia, Simpson, Benjamin K., 2019

Antioxidative peptides from proteolytic hydrolysates of false abalone (volutharpa ampullacea perryi): Characterization, identification, and molecular docking
Marine Drugs, He, Shudong, Zhang, Yi, Sun, Hanju, Du, Ming, Qiu, Jianlei, Tang, Mingming, Sun, Xianbao, Zhu, Beiwei, 2019

Genetically modified food enzymes: a review
Current Opinion in Food Science, Zhang, Yi, Geary, Timothy, Simpson, Benjamin K., 2019

A chitinase with antifungal activity from naked oat (Avena chinensis) seeds
Journal of Food Biochemistry, Li, Chen, Li, Xiaoping, Bai, Chengzhi, Zhang, Yi, Wang, Zhuanhua, 2019

Preparation of quercetin loaded microparticles and their antitumor activity against human lung cancer cells (A549) in vitro
Current Pharmaceutical Biotechnology, Li, Chen, Gao, Liufang, Zhang, Yi, Simpson, Benjamin K., 2019

Effect of beeswax and carnauba wax addition on properties of gelatin films: A comparative study
Food Bioscience, Zhang, Yi, Simpson, Benjamin K., Dumont, Marie Josée, 2018

Alcalase assisted production of novel high alpha-chain gelatin and the functional stability of its hydrogel as influenced by thermal treatment
International Journal of Biological Macromolecules, Zhang, Yi, Dutilleul, Pierre, Orsat, Valerie, Simpson, Benjamin K., 2018

Enzymes in food bioprocessing — novel food enzymes, applications, and related techniques
Current Opinion in Food Science, Zhang, Yi, He, Shudong, Simpson, Benjamin K., 2018

Physicochemical and antioxidant properties of hard white winter wheat (Triticum aestivm L.) bran superfine powder produced by eccentric vibratory milling
Powder Technology, He, Shudong, Li, Jing, He, Qian, Jian, Huifang, Zhang, Yi, Wang, Jialiang, Sun, Hanju, 2018

Hydrophobicity and physicochemical properties of agarose film as affected by chitosan addition
International Journal of Biological Macromolecules, Cao, Qiqi, Zhang, Yi, Chen, Wei, Meng, Xianghong, Liu, Bingjie, 2018

Isolation and prebiotic activity of water-soluble polysaccharides fractions from the bamboo shoots (Phyllostachys praecox)
Carbohydrate Polymers, He, Shudong, Wang, Xin, Zhang, Yi, Wang, Jing, Sun, Hanju, Wang, Junhui, Cao, Xiaodong, Ye, Yongkang, 2016